59.Kreiswirth BN,Moss A.Genotyping multidrug resistant M.tuberculosis in New York city.In:Rom WN,Garay SN,eds.Tuberculosis in Boston:Little Brown Company,1996,1199-2091
60.Salfinger M,Heifets LB.Determination of pyrazinamide M ICs for Mycobacterium tuberculosis at different pHs by the radio-metric method.Antimicrob Agents Chemother,1988,32:1002
61.Boshoff H I,Mizrahi V.Purification,gene cloning,targeted knockout,overexp ression,and biochemical characterization of the major pyrazinamidase from Mycobacterium smegmatis.J B acteriol,1998,180(22):5809
62.Scorpio A,Zhang Y.Mutations in pncA,a gene encoding pyrazinamidase/nicotinamidase,cause resistance to the antituberculous drug pyrazinamide in tubercle bacillus.Nat Med.1996,(6):662-7.
63.Cheng SJ,Thibert L,Sanchez T,et al.pncA mutations as a major mechanism of pyrazinamide resistance in Mycobacterium tuberculosis:sp read of a monoresistant strain in Quebec,Canada.Antim icrob Agents Chem other,2000,44:528
64.Miyagi C,Yamane N,Yogesh B,et al.Genetic and phenotypic characterization of pyrazinamide-resistant Mycobacterium tuberculosis comp lex isolates in Japan.Diagn Microbiol Infect Dis,2004,48:111
65.Suzuki Y,Suzuki A,Tamaru A,et al.Rap id detection of pyrazinamide-resistant Mycobacterium tuberculosis by a PCR-Based in vitro system.J Clin M icrobiol,2002,40:501
66.Alangaden GJ,L ermer SA.The clinical use of fluoroquinolones for the treatment of mycobacterial diseases.Clin Infect Dis,1997,25:1213-1221.
67.Takiff HE,Salazar L,Guerrero C,Philipp W,Huang WM,Kreiswirth B,Cole ST,Jacobs WR Jr,Telenti A.Cloning and nucleotide sequece of Mycobacterium tuberculosis gyrA and gyrB genes and detection of quino lone resistance mutations.Antimicrob Agents Chemother,1994,38:773-780.
68.Guille I,Cambau E,Jarlier V.Sequences of conserved region in the A subunit of DNA gyrase from nine species of the genus Mycobacterium:Phylogenetic analysis and implication for intrinsic susceptibility to quinolones.Antimicrob Agents Chemother,1995,39:2145-2149.
69.Guillemin I,Jarlier V ,Cambau E.Correlation between quinolone susceptibility patterns and sequences in the A and B subunits of DNA gyrase in mycobacteria.Antimicrob Agents Chemother,1998,42(8):2084-2088.
70.Cabral JM,Jackson AP,Smith CV,Shikotra N,Maxwell A,Liddington RC.Crystal structure of the breakage–reunion domain of DNA gyrase.Nature,1997,388:903-906
71.Onodera Y,TanakaM,Sato K.Inhibitory activity of quinolones against DNA gyrase of Mycrobacterium tuberculosis.J Antimicrob Chemoth,2001,47:447-450.
72.Takiff HE,Cimino M,Musso MC,et al.Efflux pump of the proton antiporter family confers low-level fluoroquinolone resistance in Mycobacterium semegamatis.PNAS,1996,93:362-366.
73.Waiters SB,Hanna BA.Testing of susceptibility of Mycobacterium tuberculosis to isoniazid and rifampin by Mycobacterium growth indicator tube method.J Clin Microbiol,1996,34:1565-1567.
74.Venkataraman P,Herbert D,Paramasivan CN.Evaluation of BACTEC radiometric method in the early diagnosis of tuberculosis.Indian J Med Res,1998,108:120-7.
75.Hanna BA,Ebrahimzadeh A,Elliott LB,et al.Multicenter evaluation of the BACTECMGIT960system for recovery of Mycobacteria.J Clin Microbiol,1999,37:748-752.
76.Pfyffer GE,Kisshug P,Rush-Gerckes S,et al.Rapid detection of Mycobacteria in clinical specimens by using the automated BACTEC 9000MB system and comparison with radiometric and solid-culture systems.J ClinMicrobiol,1997,35:2229-2234.
77.Thorpe TC,Wilson ML,Tumer JE,et al.Bact/Alert:an automated colormetric microbial detection system.J Clin Microbial,1990,28:1608-1612.
78.Woods GL,Fish G,Plauor M,et al.Clincal evaluation of the ESP culture system Ⅱfor growth and detection of Mycobacteia.J Clin Microbiol,1997,35:121-124.
79.Albert H,Heydenrych A,Brooks R,et a1.Performance of a rapid Phage-based test FAST Plaque TBTM,to diagnose pulmonary tuberculosis from sputum specimens in South Africa.Int J Tuberc Lung Dis,2002,6:529-537.
80.Marei AM,Behedy EM,Mohtady HA,et a1.Evaluation of Mycobacterium tuberculosis in clinical Samples.J Med Microbio1,2003,52:331-335.
81.Wilson SM,Suwaid ZL,Mcnemey R,et a1.Evaluation of a new rapid bacteriophage based method for the drug susceptibility testing of Mycebacterium tuberculosis.Nat Med,1997,3:65-468.
82.Eltringham JJ,Wilson SM,Drobniewki FA.Evaluation of a bacteriophage-based assay (Phage amplified biologically assay)as a rapid screen for resistance to Isoniazid,Ethambutol,Streptomycin,pyrazinamide,and ciprofloxacin among clinical isolates of Mycebacterium tuberculosis.J Clin Microbiol,1999,37:3528-3532.
83.Zhang SL,Qi H,Qiu DL,et al.Genotypic analysis of multidrug-resistant Mycobacterium tuberculosis isolates recovered from Central China.Biochem Genet,2007,45,nos 1/2(accepted)
84.Alderborn A,Kristofferson A,Hammerling U.Determination of single-nucleotide polymorphisms by real-time pyrophosphate DNA sequencing.Genome Res.2000,10(8):1249-58.
85.Ronaghi M,Karamohamed S,Pettersson B,et al.Real-time DNA sequencing using detection of pyrophosphate release.Anal Biochem,1996,242(1):84-89.
86.Nyren P,Karamohamed S,Ronaghi M.Detection of single base changes using a bioluminometric primer extension assay.Anal Biochem,1997,244(2):367-373.
87.赵锦荣,白玉杰,王琰,张庆华,罗明,闫小君.高通量测定技术检测结核分枝杆菌耐利福平的研究.中华结核和呼吸杂志,2005,28:297–300.